Rücktitelbild: Targeted Protein Upregulation of STING for Boosting the Efficacy of Immunotherapy (Angew. Chem. 18/2023)
نویسندگان
چکیده
Targeted protein upregulation by modulating the interaction between a target and its E3 ligase is strategy opposite to targeted degradation (PROTAC). In their Research Article (e202300978), Dong-Sup Lee, Seung Bum Park enhanced cellular STING levels inhibiting STING-TRIM29 interaction, which activates innate immune responses in tumor microenvironment potentiates immune-oncology treatment changing cold hot tumors. Thus, can be an alternative drug discovery for undruggable targets.
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2023
ISSN: ['1521-3773', '1433-7851', '0570-0833']
DOI: https://doi.org/10.1002/ange.202303988